The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β -lactamase in Enterobacter cloacae

The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β -lactamase in Enterobacter cloacae

Christine Miossec, Monique Claudon, Premavathy Levasseur, Michael T Black Novexel, Romainville, France Abstract: Induction of ampC β-lactamase expression can often compromise antibiotic treatment and is triggered by several β-lactams (such as cefoxitin and imipenem) and by the &...

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Main Authors: Miossec C, Claudon M, Levasseur P, Black MT
Format: Article
Language:English
Published: Dove Medical Press 2013-12-01
Series:Infection and Drug Resistance
Online Access:http://www.dovepress.com/the-beta-lactamase-inhibitor-avibactam-nxl104-does-not-induce-ampc-bet-a15161
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spelling doaj-8d3e2811c5604373a9e5d7a230a04cbd2020-11-24T20:54:34ZengDove Medical PressInfection and Drug Resistance1178-69732013-12-012013default235240The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β -lactamase in Enterobacter cloacaeMiossec CClaudon MLevasseur PBlack MTChristine Miossec, Monique Claudon, Premavathy Levasseur, Michael T Black Novexel, Romainville, France Abstract: Induction of ampC β-lactamase expression can often compromise antibiotic treatment and is triggered by several β-lactams (such as cefoxitin and imipenem) and by the β-lactamase inhibitor clavulanic acid. The novel β-lactamase inhibitor avibactam (NXL104) is a potent inhibitor of both class A and class C enzymes. The potential of avibactam for induction of ampC expression in Enterobacter cloacae was investigated by ampC messenger ribonucleic acid quantitation. Cefoxitin and clavulanic acid were confirmed as ampC inducers, whereas avibactam was found to exert no effect on ampC expression. Thus, avibactam is unlikely to diminish the activity of any partner β-lactam antibiotic against AmpC-producing organisms. Keywords: β-lactamase, ampC, induction, NXL104, avibactamhttp://www.dovepress.com/the-beta-lactamase-inhibitor-avibactam-nxl104-does-not-induce-ampc-bet-a15161
collection DOAJ
language English
format Article
sources DOAJ
author Miossec C
Claudon M
Levasseur P
Black MT
spellingShingle Miossec C
Claudon M
Levasseur P
Black MT
The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β -lactamase in Enterobacter cloacae
Infection and Drug Resistance
author_facet Miossec C
Claudon M
Levasseur P
Black MT
author_sort Miossec C
title The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β -lactamase in Enterobacter cloacae
title_short The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β -lactamase in Enterobacter cloacae
title_full The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β -lactamase in Enterobacter cloacae
title_fullStr The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β -lactamase in Enterobacter cloacae
title_full_unstemmed The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β -lactamase in Enterobacter cloacae
title_sort β-lactamase inhibitor avibactam (nxl104) does not induce ampc β -lactamase in enterobacter cloacae
publisher Dove Medical Press
series Infection and Drug Resistance
issn 1178-6973
publishDate 2013-12-01
description Christine Miossec, Monique Claudon, Premavathy Levasseur, Michael T Black Novexel, Romainville, France Abstract: Induction of ampC β-lactamase expression can often compromise antibiotic treatment and is triggered by several β-lactams (such as cefoxitin and imipenem) and by the β-lactamase inhibitor clavulanic acid. The novel β-lactamase inhibitor avibactam (NXL104) is a potent inhibitor of both class A and class C enzymes. The potential of avibactam for induction of ampC expression in Enterobacter cloacae was investigated by ampC messenger ribonucleic acid quantitation. Cefoxitin and clavulanic acid were confirmed as ampC inducers, whereas avibactam was found to exert no effect on ampC expression. Thus, avibactam is unlikely to diminish the activity of any partner β-lactam antibiotic against AmpC-producing organisms. Keywords: β-lactamase, ampC, induction, NXL104, avibactam
url http://www.dovepress.com/the-beta-lactamase-inhibitor-avibactam-nxl104-does-not-induce-ampc-bet-a15161
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