Biological Tools to Study the Effects of Environmental Contaminants at the Feto–Maternal Interface

Biological Tools to Study the Effects of Environmental Contaminants at the Feto–Maternal Interface

The identification of reproductive toxicants is a major scientific challenge for human health. Prenatal life is the most vulnerable and important time span of human development. For obvious ethical reasons, in vivo models cannot be used in human pregnancy, and animal models do not perfectly reflect...

Full description

Bibliographic Details
Main Authors: Chiara Mannelli, Francesca Ietta, Anna Maria Avanzati, Dariusz Skarzynski, Luana Paulesu
Format: Article
Language:English
Published: SAGE Publishing 2015-11-01
Series:Dose-Response
Online Access:https://doi.org/10.1177/1559325815611902
id doaj-8d347844c2014a128d25f3b6b6fe029a
record_format Article
spelling doaj-8d347844c2014a128d25f3b6b6fe029a2020-11-25T03:32:32ZengSAGE PublishingDose-Response1559-32582015-11-011310.1177/155932581561190210.1177_1559325815611902Biological Tools to Study the Effects of Environmental Contaminants at the Feto–Maternal InterfaceChiara Mannelli0Francesca Ietta1Anna Maria Avanzati2Dariusz Skarzynski3Luana Paulesu4Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, PolandDepartment of Life Sciences, University of Siena, Siena, ItalyDepartment of Life Sciences, University of Siena, Siena, ItalyDepartment of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, PolandDepartment of Life Sciences, University of Siena, Siena, ItalyThe identification of reproductive toxicants is a major scientific challenge for human health. Prenatal life is the most vulnerable and important time span of human development. For obvious ethical reasons, in vivo models cannot be used in human pregnancy, and animal models do not perfectly reflect human physiology. This review describes the in vitro test models representative of the human feto–maternal interface and the effects of environmental chemicals with estrogen-like activity, mainly bisphenol A and para-nonylphenol, with a particular emphasis on the effects at low, nontoxic doses similar to concentrations commonly detected in the population.https://doi.org/10.1177/1559325815611902
collection DOAJ
language English
format Article
sources DOAJ
author Chiara Mannelli
Francesca Ietta
Anna Maria Avanzati
Dariusz Skarzynski
Luana Paulesu
spellingShingle Chiara Mannelli
Francesca Ietta
Anna Maria Avanzati
Dariusz Skarzynski
Luana Paulesu
Biological Tools to Study the Effects of Environmental Contaminants at the Feto–Maternal Interface
Dose-Response
author_facet Chiara Mannelli
Francesca Ietta
Anna Maria Avanzati
Dariusz Skarzynski
Luana Paulesu
author_sort Chiara Mannelli
title Biological Tools to Study the Effects of Environmental Contaminants at the Feto–Maternal Interface
title_short Biological Tools to Study the Effects of Environmental Contaminants at the Feto–Maternal Interface
title_full Biological Tools to Study the Effects of Environmental Contaminants at the Feto–Maternal Interface
title_fullStr Biological Tools to Study the Effects of Environmental Contaminants at the Feto–Maternal Interface
title_full_unstemmed Biological Tools to Study the Effects of Environmental Contaminants at the Feto–Maternal Interface
title_sort biological tools to study the effects of environmental contaminants at the feto–maternal interface
publisher SAGE Publishing
series Dose-Response
issn 1559-3258
publishDate 2015-11-01
description The identification of reproductive toxicants is a major scientific challenge for human health. Prenatal life is the most vulnerable and important time span of human development. For obvious ethical reasons, in vivo models cannot be used in human pregnancy, and animal models do not perfectly reflect human physiology. This review describes the in vitro test models representative of the human feto–maternal interface and the effects of environmental chemicals with estrogen-like activity, mainly bisphenol A and para-nonylphenol, with a particular emphasis on the effects at low, nontoxic doses similar to concentrations commonly detected in the population.
url https://doi.org/10.1177/1559325815611902
work_keys_str_mv AT chiaramannelli biologicaltoolstostudytheeffectsofenvironmentalcontaminantsatthefetomaternalinterface
AT francescaietta biologicaltoolstostudytheeffectsofenvironmentalcontaminantsatthefetomaternalinterface
AT annamariaavanzati biologicaltoolstostudytheeffectsofenvironmentalcontaminantsatthefetomaternalinterface
AT dariuszskarzynski biologicaltoolstostudytheeffectsofenvironmentalcontaminantsatthefetomaternalinterface
AT luanapaulesu biologicaltoolstostudytheeffectsofenvironmentalcontaminantsatthefetomaternalinterface
_version_ 1724567644721381376

Similar Items