Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

A possible undesired outcome of CRISPR-Cas9 germline editing is unwanted karyotype alterations. Here the authors track aberrations through three divisions of embryonic development following Cas9 editing.

Bibliographic Details
Main Authors: Stamatis Papathanasiou, Styliani Markoulaki, Logan J. Blaine, Mitchell L. Leibowitz, Cheng-Zhong Zhang, Rudolf Jaenisch, David Pellman
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26097-y
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spelling doaj-8d2a4609b9d444b99c1baa3c896460092021-10-10T11:44:19ZengNature Publishing GroupNature Communications2041-17232021-10-011211710.1038/s41467-021-26097-yWhole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editingStamatis Papathanasiou0Styliani Markoulaki1Logan J. Blaine2Mitchell L. Leibowitz3Cheng-Zhong Zhang4Rudolf Jaenisch5David Pellman6Department of Cell Biology, Blavatnik Institute, Harvard Medical SchoolWhitehead InstituteDepartment of Cell Biology, Blavatnik Institute, Harvard Medical SchoolDepartment of Cell Biology, Blavatnik Institute, Harvard Medical SchoolDepartment of Biomedical Informatics, Harvard Medical SchoolWhitehead InstituteDepartment of Cell Biology, Blavatnik Institute, Harvard Medical SchoolA possible undesired outcome of CRISPR-Cas9 germline editing is unwanted karyotype alterations. Here the authors track aberrations through three divisions of embryonic development following Cas9 editing.https://doi.org/10.1038/s41467-021-26097-y
collection DOAJ
language English
format Article
sources DOAJ
author Stamatis Papathanasiou
Styliani Markoulaki
Logan J. Blaine
Mitchell L. Leibowitz
Cheng-Zhong Zhang
Rudolf Jaenisch
David Pellman
spellingShingle Stamatis Papathanasiou
Styliani Markoulaki
Logan J. Blaine
Mitchell L. Leibowitz
Cheng-Zhong Zhang
Rudolf Jaenisch
David Pellman
Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
Nature Communications
author_facet Stamatis Papathanasiou
Styliani Markoulaki
Logan J. Blaine
Mitchell L. Leibowitz
Cheng-Zhong Zhang
Rudolf Jaenisch
David Pellman
author_sort Stamatis Papathanasiou
title Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
title_short Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
title_full Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
title_fullStr Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
title_full_unstemmed Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
title_sort whole chromosome loss and genomic instability in mouse embryos after crispr-cas9 genome editing
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-10-01
description A possible undesired outcome of CRISPR-Cas9 germline editing is unwanted karyotype alterations. Here the authors track aberrations through three divisions of embryonic development following Cas9 editing.
url https://doi.org/10.1038/s41467-021-26097-y
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AT stylianimarkoulaki wholechromosomelossandgenomicinstabilityinmouseembryosaftercrisprcas9genomeediting
AT loganjblaine wholechromosomelossandgenomicinstabilityinmouseembryosaftercrisprcas9genomeediting
AT mitchelllleibowitz wholechromosomelossandgenomicinstabilityinmouseembryosaftercrisprcas9genomeediting
AT chengzhongzhang wholechromosomelossandgenomicinstabilityinmouseembryosaftercrisprcas9genomeediting
AT rudolfjaenisch wholechromosomelossandgenomicinstabilityinmouseembryosaftercrisprcas9genomeediting
AT davidpellman wholechromosomelossandgenomicinstabilityinmouseembryosaftercrisprcas9genomeediting
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