The evolution of substrate discrimination in macrolide antibiotic resistance enzymes

New antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutations that expand the substrate range of antibiotic-...

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Main Authors:	Andrew C. Pawlowski, Peter J. Stogios, Kalinka Koteva, Tatiana Skarina, Elena Evdokimova, Alexei Savchenko, Gerard D. Wright
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02680-0

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spelling	doaj-8d1fd42155f34c23acbadc3b6245e7ca2021-05-11T10:19:21ZengNature Publishing GroupNature Communications2041-17232018-01-019111210.1038/s41467-017-02680-0The evolution of substrate discrimination in macrolide antibiotic resistance enzymesAndrew C. Pawlowski0Peter J. Stogios1Kalinka Koteva2Tatiana Skarina3Elena Evdokimova4Alexei Savchenko5Gerard D. Wright6Michael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster UniversityDepartment of Chemical Engineering and Applied Chemistry, University of TorontoMichael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster UniversityDepartment of Chemical Engineering and Applied Chemistry, University of TorontoDepartment of Chemical Engineering and Applied Chemistry, University of TorontoDepartment of Chemical Engineering and Applied Chemistry, University of TorontoMichael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster UniversityNew antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutations that expand the substrate range of antibiotic-inactivating enzymes.https://doi.org/10.1038/s41467-017-02680-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Andrew C. Pawlowski Peter J. Stogios Kalinka Koteva Tatiana Skarina Elena Evdokimova Alexei Savchenko Gerard D. Wright
spellingShingle	Andrew C. Pawlowski Peter J. Stogios Kalinka Koteva Tatiana Skarina Elena Evdokimova Alexei Savchenko Gerard D. Wright The evolution of substrate discrimination in macrolide antibiotic resistance enzymes Nature Communications
author_facet	Andrew C. Pawlowski Peter J. Stogios Kalinka Koteva Tatiana Skarina Elena Evdokimova Alexei Savchenko Gerard D. Wright
author_sort	Andrew C. Pawlowski
title	The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
title_short	The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
title_full	The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
title_fullStr	The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
title_full_unstemmed	The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
title_sort	evolution of substrate discrimination in macrolide antibiotic resistance enzymes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	New antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutations that expand the substrate range of antibiotic-inactivating enzymes.
url	https://doi.org/10.1038/s41467-017-02680-0
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The evolution of substrate discrimination in macrolide antibiotic resistance enzymes

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