Modeling human hepatic steatosis in pluripotent stem cell-derived hepatocytes

Modeling human hepatic steatosis in pluripotent stem cell-derived hepatocytes

Summary: This protocol describes the production of hepatocyte-like cells (HLCs) from human pluripotent stem cells and how to induce hepatic steatosis, a condition characterized by intracellular lipid accumulation. Following differentiation to an HLC phenotype, intracellular lipid accumulation is ind...

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Bibliographic Details
Main Authors: Matthew C. Sinton, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Amanda J. Drake, David C. Hay
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:STAR Protocols
Subjects:
Cell Differentiation
Stem Cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166721002008

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