Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption

Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption

Bibliographic Details
Main Authors: Kun Jia, Zongyang Lu, Fei Zhou, Zhiqi Xiong, Rui Zhang, Zhiwei Liu, Yu’e Ma, Lei He, Cong Li, Zhen Zhu, Dejing Pan, Zhengxing Lian
Format: Article
Language:English
Published: SpringerOpen 2019-02-01
Series:Protein & Cell
Online Access:http://link.springer.com/article/10.1007/s13238-019-0611-6
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spelling doaj-8d0f44ef5c3d4aca85d9b5efad5c22cf2020-11-25T00:29:40ZengSpringerOpenProtein & Cell1674-800X1674-80182019-02-01101183283910.1007/s13238-019-0611-6Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruptionKun Jia0Zongyang Lu1Fei Zhou2Zhiqi Xiong3Rui Zhang4Zhiwei Liu5Yu’e Ma6Lei He7Cong Li8Zhen Zhu9Dejing Pan10Zhengxing Lian11Beijing Key Laboratory of Animal Genetic Improvement, China Agricultural UniversitySchool of Life Science and Technology, ShanghaiTech UniversityCambridge-Suda Genomic Resource Center and Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow UniversitySchool of Life Science and Technology, ShanghaiTech UniversityBeijing Key Laboratory of Animal Genetic Improvement, China Agricultural UniversityCambridge-Suda Genomic Resource Center and Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow UniversityCambridge-Suda Genomic Resource Center and Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow UniversityCambridge-Suda Genomic Resource Center and Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow UniversityCambridge-Suda Genomic Resource Center and Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow UniversityKey Laboratory of MEMS of Ministry of Education, Southeast UniversityCambridge-Suda Genomic Resource Center and Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, Soochow UniversityBeijing Key Laboratory of Animal Genetic Improvement, China Agricultural Universityhttp://link.springer.com/article/10.1007/s13238-019-0611-6
collection DOAJ
language English
format Article
sources DOAJ
author Kun Jia
Zongyang Lu
Fei Zhou
Zhiqi Xiong
Rui Zhang
Zhiwei Liu
Yu’e Ma
Lei He
Cong Li
Zhen Zhu
Dejing Pan
Zhengxing Lian
spellingShingle Kun Jia
Zongyang Lu
Fei Zhou
Zhiqi Xiong
Rui Zhang
Zhiwei Liu
Yu’e Ma
Lei He
Cong Li
Zhen Zhu
Dejing Pan
Zhengxing Lian
Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption
Protein & Cell
author_facet Kun Jia
Zongyang Lu
Fei Zhou
Zhiqi Xiong
Rui Zhang
Zhiwei Liu
Yu’e Ma
Lei He
Cong Li
Zhen Zhu
Dejing Pan
Zhengxing Lian
author_sort Kun Jia
title Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption
title_short Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption
title_full Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption
title_fullStr Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption
title_full_unstemmed Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption
title_sort multiple sgrnas facilitate base editing-mediated i-stop to induce complete and precise gene disruption
publisher SpringerOpen
series Protein & Cell
issn 1674-800X
1674-8018
publishDate 2019-02-01
url http://link.springer.com/article/10.1007/s13238-019-0611-6
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AT zongyanglu multiplesgrnasfacilitatebaseeditingmediatedistoptoinducecompleteandprecisegenedisruption
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AT zhiqixiong multiplesgrnasfacilitatebaseeditingmediatedistoptoinducecompleteandprecisegenedisruption
AT ruizhang multiplesgrnasfacilitatebaseeditingmediatedistoptoinducecompleteandprecisegenedisruption
AT zhiweiliu multiplesgrnasfacilitatebaseeditingmediatedistoptoinducecompleteandprecisegenedisruption
AT yuema multiplesgrnasfacilitatebaseeditingmediatedistoptoinducecompleteandprecisegenedisruption
AT leihe multiplesgrnasfacilitatebaseeditingmediatedistoptoinducecompleteandprecisegenedisruption
AT congli multiplesgrnasfacilitatebaseeditingmediatedistoptoinducecompleteandprecisegenedisruption
AT zhenzhu multiplesgrnasfacilitatebaseeditingmediatedistoptoinducecompleteandprecisegenedisruption
AT dejingpan multiplesgrnasfacilitatebaseeditingmediatedistoptoinducecompleteandprecisegenedisruption
AT zhengxinglian multiplesgrnasfacilitatebaseeditingmediatedistoptoinducecompleteandprecisegenedisruption
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