Interleukin-2-Inducible T-Cell Kinase Deficiency—New Patients, New Insight?

Interleukin-2-Inducible T-Cell Kinase Deficiency—New Patients, New Insight?

Patients with primary immunodeficiency can be prone to severe Epstein–Barr virus (EBV) associated immune dysregulation. Individuals with mutations in the interleukin-2-inducible T-cell kinase (ITK) gene experience Hodgkin and non-Hodgkin lymphoma, EBV lymphoproliferative disease, hemophagocytic lymp...

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Bibliographic Details
Main Authors: Sujal Ghosh, Ingo Drexler, Sanil Bhatia, Heiko Adler, Andrew R. Gennery, Arndt Borkhardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
primary immunodeficiency
combined immunodeficiency
interleukin-2-inducible T-cell kinase
Epstein–Barr virus-related malignancies
lymphoproliferative disorders
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.00979/full

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