The Asymmetric A<sup>3</sup>(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines

The Asymmetric A<sup>3</sup>(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines

The recent developments in asymmetric A<sup>3</sup> (aldehyde&#8211;alkyne&#8211;amine) coupling has been summarized in this review. Several interesting modifications of the ligands enabled the highly enantioselective synthesis of chiral propargylamines, which are further used in...

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Main Authors: Jia-Nan Mo, Junqi Su, Jiannan Zhao
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
aldehydes
alkynes
amines
asymmetric catalysis
copper
multicomponent reactions
nitrogen heterocycles
Online Access:https://www.mdpi.com/1420-3049/24/7/1216
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spelling doaj-8cee17fec5954aa3b0b65f5439aca7622020-11-24T20:48:02ZengMDPI AGMolecules1420-30492019-03-01247121610.3390/molecules24071216molecules24071216The Asymmetric A<sup>3</sup>(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to PropargylaminesJia-Nan Mo0Junqi Su1Jiannan Zhao2Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024, ChinaZhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024, ChinaZhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024, ChinaThe recent developments in asymmetric A<sup>3</sup> (aldehyde&#8211;alkyne&#8211;amine) coupling has been summarized in this review. Several interesting modifications of the ligands enabled the highly enantioselective synthesis of chiral propargylamines, which are further used in the construction of nitrogen-containing chiral building blocks.https://www.mdpi.com/1420-3049/24/7/1216aldehydesalkynesaminesasymmetric catalysiscoppermulticomponent reactionsnitrogen heterocycles
collection DOAJ
language English
format Article
sources DOAJ
author Jia-Nan Mo
Junqi Su
Jiannan Zhao
spellingShingle Jia-Nan Mo
Junqi Su
Jiannan Zhao
The Asymmetric A<sup>3</sup>(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
Molecules
aldehydes
alkynes
amines
asymmetric catalysis
copper
multicomponent reactions
nitrogen heterocycles
author_facet Jia-Nan Mo
Junqi Su
Jiannan Zhao
author_sort Jia-Nan Mo
title The Asymmetric A<sup>3</sup>(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
title_short The Asymmetric A<sup>3</sup>(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
title_full The Asymmetric A<sup>3</sup>(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
title_fullStr The Asymmetric A<sup>3</sup>(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
title_full_unstemmed The Asymmetric A<sup>3</sup>(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
title_sort asymmetric a<sup>3</sup>(aldehyde–alkyne–amine) coupling: highly enantioselective access to propargylamines
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2019-03-01
description The recent developments in asymmetric A<sup>3</sup> (aldehyde&#8211;alkyne&#8211;amine) coupling has been summarized in this review. Several interesting modifications of the ligands enabled the highly enantioselective synthesis of chiral propargylamines, which are further used in the construction of nitrogen-containing chiral building blocks.
topic aldehydes
alkynes
amines
asymmetric catalysis
copper
multicomponent reactions
nitrogen heterocycles
url https://www.mdpi.com/1420-3049/24/7/1216
work_keys_str_mv AT jiananmo theasymmetricasup3supaldehydealkyneaminecouplinghighlyenantioselectiveaccesstopropargylamines
AT junqisu theasymmetricasup3supaldehydealkyneaminecouplinghighlyenantioselectiveaccesstopropargylamines
AT jiannanzhao theasymmetricasup3supaldehydealkyneaminecouplinghighlyenantioselectiveaccesstopropargylamines
AT jiananmo asymmetricasup3supaldehydealkyneaminecouplinghighlyenantioselectiveaccesstopropargylamines
AT junqisu asymmetricasup3supaldehydealkyneaminecouplinghighlyenantioselectiveaccesstopropargylamines
AT jiannanzhao asymmetricasup3supaldehydealkyneaminecouplinghighlyenantioselectiveaccesstopropargylamines
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