A case of toxic epidermal necrolysis probably due to etoricoxib

• Main Authors: Sayanta Thakur, Sandeep Lahiry
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2019-01-01
• Series: Journal of Current Research in Scientific Medicine
• Subjects: adverse drug reaction; etoricoxib; toxic epidermal necrolysis
• Online Access: http://www.jcrsmed.org/article.asp?issn=2455-3069;year=2019;volume=5;issue=2;spage=118;epage=121;aulast=Thakur

This case report describes a rare incidence of etoricoxib-induced toxic epidermal necrolysis (TEN) in a 25-year-old woman. The patient presented with rapidly evolving rashes, initially over the face and upper body but subsequently involving the total body surface area. There was an extensive ulceration of buccal mucosa along with eyelid edema, crusting, and corneal ulceration. Naranjo's and WHO–UMC score for this adverse event was “seven;” hence, causality was “probable.” SCORTEN (severity-of-illness score) was “one” with a predicted mortality of 3.2%. Due to persistent hypotension and risk of impending sepsis, aggressive fluid resuscitation and antibiotics were initiated. Cyclosporine and systemic steroids were added later, following which the patient had a prompt recovery. She was discharged after 28 days of hospitalization. However, etoricoxib-induced TEN is a rare clinical association, with very few previously reported cases.