Radiosensitization of Human Leukemic HL-60 Cells by ATR Kinase Inhibitor (VE-821): Phosphoproteomic Analysis

Radiosensitization of Human Leukemic HL-60 Cells by ATR Kinase Inhibitor (VE-821): Phosphoproteomic Analysis

DNA damaging agents such as ionizing radiation or chemotherapy are frequently used in oncology. DNA damage response (DDR)—triggered by radiation-induced double strand breaks—is orchestrated mainly by three Phosphatidylinositol 3-kinase-related kinases (PIKKs): Ataxia teleangiectasia mutated (ATM), D...

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Bibliographic Details
Main Authors: Barbora Šalovská, Ivo Fabrik, Kamila Ďurišová, Marek Link, Jiřina Vávrová, Martina Řezáčová, Aleš Tichý
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:International Journal of Molecular Sciences
Subjects:
small-molecule kinase inhibitors
VE-821
ATR kinase
DNA damage response
radio-sensitization
quantitative phosphoproteomics
titanium dioxide chromatography
SILAC
leukemia
HL-60 cells
Online Access:http://www.mdpi.com/1422-0067/15/7/12007

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http://www.mdpi.com/1422-0067/15/7/12007

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