IL-6 stimulates intestinal epithelial proliferation and repair after injury.
IL-6 is a pleiotropic cytokine often associated with inflammation. Inhibition of this pathway has led to successful treatment of rheumatoid arthritis, but one unforeseen potential complication of anti-IL-6 therapy is bowel perforation. Within the intestine, IL-6 has been shown to prevent epithelial...
Main Authors: | Kristine A Kuhn, Nicholas A Manieri, Ta-Chiang Liu, Thaddeus S Stappenbeck |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4257684?pdf=render |
Similar Items
-
Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells.
by: Gwanghee Lee, et al.
Published: (2011-01-01) -
IL-1 stimulates ceramide accumulation without
inducing apoptosis in intestinal epithelial cells
by: Fadia R. Homaidan, et al.
Published: (2002-01-01) -
Human intestinal epithelial and smooth muscle cells are potent producers of IL-6
by: Edmond K. Ng, et al.
Published: (2003-01-01) -
Mitochondrial function controls intestinal epithelial stemness and proliferation
by: Emanuel Berger, et al.
Published: (2016-10-01) -
Kiwifruit drives human microbiota-derived DNA to stimulate IL-7 secretion in intestinal epithelial cells
by: Gunaranjan Paturi, et al.
Published: (2020-04-01)