Dual Topology of the Melanocortin-2 Receptor Accessory Protein (MRAP) Is Stable

Dual Topology of the Melanocortin-2 Receptor Accessory Protein (MRAP) Is Stable

MRAP (melanocortin 2 receptor accessory protein) facilitates trafficking of melanocortin 2 (MC2) receptors and is essential for ACTH binding and signaling. MRAP is a single transmembrane domain protein that forms antiparallel homodimers. These studies ask when MRAP first acquires this dual topology,...

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Bibliographic Details
Main Authors: Zachary J. Maben, Sundeep Malik, Liyi H. Jiang, Patricia M Hinkle
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Endocrinology
Subjects:
Ubiquitin
ACTH
cAMP
accessory protein
MRAP
Membrane protein topology
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00096/full

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