SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral Pathogenesis

SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral Pathogenesis

At the surge of the coronavirus disease 2019 (COVID-19) pandemic, we detected and identified six functional domains (I to VI) in the SARS-CoV-2 3a protein. Our analysis showed that the functional domains were linked to virulence, infectivity, ion channel formation, and virus release in SARS-CoV-2 3a...

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Bibliographic Details
Main Authors: Elio Issa, Georgi Merhi, Balig Panossian, Tamara Salloum, Sima Tokajian
Format: Article
Language:English
Published: American Society for Microbiology 2020-05-01
Series:mSystems
Subjects:
3a protein
covid-19
nonsynonymous mutations
orf3a
sars-cov-2
Online Access:https://doi.org/10.1128/mSystems.00266-20

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