Evaluation of the regenerative potential of 25&#x0025; doxycycline-loaded biodegradable membrane <i> vs</i> biodegradable membrane alone in the treatment of human periodontal infrabony defects: A clinical and radiological study

• Main Authors: Chaturvedi Rashi, Gill Amarjit, Sikri Poonam
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2008-01-01
• Series: Indian Journal of Dental Research
• Subjects: Antimicrobial agents; host modulation; infection; microbial colonization; regeneration
• Online Access: http://www.ijdr.in/article.asp?issn=0970-9290;year=2008;volume=19;issue=2;spage=116;epage=123;aulast=Chaturvedi

<b>Background:</b> Microbial colonization of the barrier membranes used for guided tissue regeneration is inevitable and can lead to delayed healing. <b> Aims:</b> Antimicrobial coating of the membrane with 25&#x0025; doxycycline paste has been attempted to prevent infection and achieve enhanced regeneration in periodontal infrabony defects. <b> Materials and Methods:</b> Twenty-four patients with 2-walled or 3-walled infrabony defects were selected and randomly divided into two equal groups. Infrabony defects of group A were treated with a biodegradable membrane coated with 25&#x0025; doxycycline while those of group B were treated with membrane alone. Clinical assessment of probing depth and attachment level and radiographic evaluation of the defect depth was done preoperatively and at 12 and 24 weeks postoperatively. <b> Statistical Analysis:</b> The relative efficacy of the two treatment modalities were evaluated using the paired Student&#x2032;s <i> t-</i> test and the comparative evaluation between the two groups was done using the independent Student&#x2032;s <i> t</i> -test. <b> Results:</b> Both the groups exhibited a highly significant reduction in probing depth and gain in clinical attachment level and linear bone fill at the end of 24 weeks. Comparative evaluation between the two study groups revealed a significant reduction in probing depth (<i> P</i> = 0.016^FNx01 ) and linear bone fill (<i> P</i> = 0.02^FNx01 ) in group A as compared to group B. Mean gain in attachment level was greater for group A than for group B but the difference was statistically nonsignificant (<i> P</i> = 0.065^NS ). <b> Conclusions:</b> The results suggest that doxycycline is beneficial in reducing membrane-associated infection and can potentiate regeneration through host modulation.