Revisited analysis of a SHIVA01 trial cohort using functional mutational analyses successfully predicted treatment outcome

Revisited analysis of a SHIVA01 trial cohort using functional mutational analyses successfully predicted treatment outcome

It still remains to be demonstrated that using molecular profiling to guide therapy improves patient outcome in oncology. Classification of somatic variants is not straightforward, rendering treatment decisions based on variants with unknown significance (VUS) hard to implement. The oncogenic activi...

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Bibliographic Details
Main Authors: Maud Kamal, Gabi Tarcic, Sylvain Dureau, Oded Edelheit, Zohar Barbash, Charlotte Lecerf, Claire Morel, Benjamin Miron, Celine Callens, Nicolas Servant, Ivan Bieche, Michael Vidne, Christophe Le Tourneau
Format: Article
Language:English
Published: Wiley 2018-05-01
Series:Molecular Oncology
Subjects:
drug response
in vitro functional assay
mutation
oncogenic activity
variant with unknown significance
Online Access:https://doi.org/10.1002/1878-0261.12180

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