Homogeneous polyporus polysaccharide inhibits bladder cancer by polarizing macrophages to M1 subtype in tumor microenvironment

Homogeneous polyporus polysaccharide inhibits bladder cancer by polarizing macrophages to M1 subtype in tumor microenvironment

Abstract Background Polyporus polysaccharide (PPS), an active ingredient of traditional Chinese medicinal Polyporus umbellatus, has multiple biological functions, such as anti-cancer, immune-regulating and hepatoprotective activities. The purpose of this study was to investigate the mechanism of hom...

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Bibliographic Details
Main Authors: Wenyu Jia, Siwan Luo, Gena Lai, Shiqi Li, Shuai Huo, Meifang Li, Xing Zeng
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Bladder cancer
Homogeneous polyporus polysaccharide
THP-1-derived macrophage
Tumor microenvironment
JAK2/NF-κB pathway
Online Access:https://doi.org/10.1186/s12906-021-03318-x

Internet

https://doi.org/10.1186/s12906-021-03318-x

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