Silencing of X-Linked MicroRNAs by Meiotic Sex Chromosome Inactivation.

Silencing of X-Linked MicroRNAs by Meiotic Sex Chromosome Inactivation.

During the pachytene stage of meiosis in male mammals, the X and Y chromosomes are transcriptionally silenced by Meiotic Sex Chromosome Inactivation (MSCI). MSCI is conserved in therian mammals and is essential for normal male fertility. Transcriptomics approaches have demonstrated that in mice, mos...

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Bibliographic Details
Main Authors: Hélène Royo, Hervé Seitz, Elias ElInati, Antoine H F M Peters, Michael B Stadler, James M A Turner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4624941?pdf=render

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