How Can We Improve the Detection of Alpha1-Antitrypsin Deficiency?

How Can We Improve the Detection of Alpha1-Antitrypsin Deficiency?

The Z deficiency in α1-antitrypsin (A1ATD) is an under-recognized condition. Alpha1-antitrypsin (A1AT) is the main protein in the α1-globulin fraction of serum protein electrophoresis (SPE); however, evaluation of the α1-globulin protein fraction has received very little attention. Serum Z-type A1AT...

Full description

Bibliographic Details
Main Authors:	Ilaria Ferrarotti, Beata Poplawska-Wisniewska, Maria Teresa Trevisan, Janine Koepke, Marc Dresel, Rembert Koczulla, Stefania Ottaviani, Raffaele Baldo, Marina Gorrini, Giorgia Sala, Luana Cavallon, Tobias Welte, Joanna Chorostowska-Wynimko, Maurizio Luisetti, Sabina Janciauskiene
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4536179?pdf=render

Similar Items

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications
by: Chapman KR, et al.
Published: (2018-01-01)

The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions
by: Sabina Janciauskiene, et al.
Published: (2018-04-01)

Therapy with plasma purified alpha1-antitrypsin (Prolastin®) induces time-dependent changes in plasma levels of MMP-9 and MPO.
by: Janine Koepke, et al.
Published: (2015-01-01)

Does Augmentation with Alpha1-Antitrypsin Affect Neutrophil Extracellular Traps Formation?
by: Eileen Frenzel, Elena Korenbaum, Jan Hegermann, Matthias Ochs, Janine Koepke, Andreas Rembert Koczulla, Tobias Welte, Thomas Köhnlein, Sabina Janciauskiene
Published: (2012-01-01)

Post-Translational Modifications of Circulating Alpha-1-Antitrypsin Protein
by: Urszula Lechowicz, et al.
Published: (2020-12-01)

Targeted screening programmes in COPD: how to identify individuals with α1-antitrypsin deficiency
by: Joanna Chorostowska-Wynimko
Published: (2015-03-01)

New Patient-Centric Approaches to the Management of Alpha-1 Antitrypsin Deficiency
by: Chorostowska-Wynimko J, et al.
Published: (2020-02-01)

Does urinary peptide content differ between COPD patients with and without inherited alpha-1 antitrypsin deficiency?
by: Carleo A, et al.
Published: (2017-03-01)

Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency
by: Koczulla A-Rembert, et al.
Published: (2012-05-01)

Diagnostic delay and clinical modifiers in alpha-1 antitrypsin deficiency
by: Thomas Köhnlein, et al.
Published: (2010-10-01)

Alpha1-antitrypsin deficiency – misconceptions about an important clinical problem
by: Paweł Jan Kuca, et al.
Published: (2015-10-01)

Update on α1-antitrypsin deficiency
by: Ilaria Ferrarotti, et al.
Published: (2018-06-01)

Screening for Alpha 1 antitrypsin deficiency in Tunisian subjects with obstructive lung disease: a feasibility report
by: Chibani Jemni, et al.
Published: (2009-04-01)

The effects of weekly augmentation therapy in patients with PiZZ &alpha;1-antitrypsin deficiency
by: Schmid ST, et al.
Published: (2012-09-01)

Case-finding for alpha1-antitrypsin deficiency in Kazakh patients with COPD
by: Ardak Zhumagaliyeva, et al.
Published: (2017-10-01)

Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency alleles
by: F.J. de Serres, et al.
Published: (2005-09-01)

Alpha1-antitrypsin protects lung cancer cells from staurosporine-induced apoptosis: the role of bacterial lipopolysaccharide
by: Natalie Schwarz, et al.
Published: (2020-06-01)

Concentration-dependent effects of native and polymerised α1-antitrypsin on primary human monocytes, <it>in vitro</it>
by: Jansson Lennart, et al.
Published: (2004-03-01)

Alpha-1 antitrypsin deficiency impairs lung antibacterial immunity in mice
by: Lena Ostermann, et al.
Published: (2021-02-01)

Why do some adults with PiMZ α1-antitrypsin develop bronchiectasis?
by: Nupur Aggarwal, et al.
Published: (2016-06-01)

Potential Roles of Acute Phase Proteins in Cancer: Why Do Cancer Cells Produce or Take Up Exogenous Acute Phase Protein Alpha1-Antitrypsin?
by: Sabina Janciauskiene, et al.
Published: (2021-02-01)

Alpha-1 antitrypsin deficiency: from Italy to the world
by: B. Balbi, et al.
Published: (2016-02-01)

The Distribution of Alpha-1 Antitrypsin Genotypes Between Patients with COPD/Emphysema, Asthma and Bronchiectasis
by: Veith M, et al.
Published: (2020-11-01)

Cardiovascular risk in patients with alpha-1-antitrypsin deficiency
by: Sebastian Fähndrich, et al.
Published: (2017-09-01)

A Novel Mouse Monoclonal Antibody C42 against C-Terminal Peptide of Alpha-1-Antitrypsin
by: Srinu Tumpara, et al.
Published: (2021-02-01)

α-Linoleic Acid Enhances the Capacity of α1-Antitrypsin to Inhibit Lipopolysaccharide-Induced IL-1β in Human Blood Neutrophils
by: Nupur Aggarwal, et al.
Published: (2016-07-01)

The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant
by: Riccardo Ronzoni, et al.
Published: (2021-05-01)

Prolastin, a pharmaceutical preparation of purified human α1-antitrypsin, blocks endotoxin-mediated cytokine release
by: Westin Ulla, et al.
Published: (2005-01-01)

Improving the Lives of Patients with Alpha-1 Antitrypsin Deficiency
by: Sandhaus RA, et al.
Published: (2020-12-01)

Three new alpha1-antitrypsin deficiency variants help to define a C-terminal region regulating conformational change and polymerization.
by: Anna M Fra, et al.
Published: (2012-01-01)

Endotoxin receptor CD14 in PiZ α-1-antitrypsin deficiency individuals
by: Sveger Tomas, et al.
Published: (2008-04-01)

SP-A binds alpha<sub>1</sub>-antitrypsin <it>in vitro </it>and reduces the association rate constant for neutrophil elastase
by: Carrabino Natalia, et al.
Published: (2005-12-01)

Diagnosis and management of α1-antitrypsin deficiency in Europe: an expert survey
by: Ildikó Horváth, et al.
Published: (2019-03-01)

α1-antitrypsin and its C-terminal fragment attenuate effects of degranulated neutrophil-conditioned medium on lung cancer HCC cells, <it>in vitro</it>
by: Westin Ulla, et al.
Published: (2004-11-01)

The Delivery of α1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore
by: Srinu Tumpara, et al.
Published: (2020-07-01)

Clinical manifestations in patients with PI*MMMalton genotypes. A matter still unsolved in alpha‐1 antitrypsin deficiency
by: Marina Aiello, et al.
Published: (2020-04-01)

Protocol for the EARCO Registry: a pan-European observational study in patients with α1-antitrypsin deficiency
by: Timm Greulich, et al.
Published: (2020-03-01)

α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes
by: Taraneh Ebrahimi, et al.
Published: (2018-09-01)

Alpha-1 Antitrypsin Z Variant (AAT PI*Z) as a Risk Factor for Intrahepatic Cholestasis of Pregnancy
by: Przemyslaw Kosinski, et al.
Published: (2021-09-01)

Boosted Pro-Inflammatory Activity in Human PBMCs by Lipopolysaccharide and SARS-CoV-2 Spike Protein Is Regulated by α-1 Antitrypsin
by: Srinu Tumpara, et al.
Published: (2021-07-01)