An efficient strategy for heterologous expression and purification of active peptide hainantoxin-IV.

An efficient strategy for heterologous expression and purification of active peptide hainantoxin-IV.

Hainantoxin-IV (HNTX-IV) from the venom of the spider Selenocosmia hainana is a potent antagonist that specifically inhibits the tetrodotoxin-sensitive (TTX-S) sodium channels. The toxin peptide consists of 35 amino acids and adopts a typical inhibitory cystine knot (ICK) motif. To obtain adequate H...

Full description

Bibliographic Details
Main Authors: Hui Zhang, Peng-Fei Huang, Er Meng, Wen-Ying Li, Lu Zhou, Ling-Yun Zhu, Lei Wu, Meng-Jie Li, Song-Ping Liang, Dong-Yi Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4315428?pdf=render

Similar Items

Similar Items