Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells

Abstract Only 40% of patients with advanced ovarian cancer survive more than 5 years. We have previously shown that pitavastatin induces regression of ovarian cancer xenografts in mice. To evaluate whether the response of ovarian cancer cells to pitavastatin is potentiated by farnesyl diphosphate sy...

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Bibliographic Details
Main Authors: Marwan Ibrahim Abdullah, Mohammed Najim Abed, Alan Richardson
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08649-9

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