Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause

Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause

Embryonic diapause is a state of dormancy with poorly understood mechanisms of embryo intrinsic regulation. Here, the authors show that murine diapause is a dynamic process, where tissue-scale reorganization of the pluripotent lineage is controlled in an autocrine manner by the Wnt/b-catenin/Esrrb s...

Full description

Bibliographic Details
Main Authors: Rui Fan, Yung Su Kim, Jie Wu, Rui Chen, Dagmar Zeuschner, Karina Mildner, Kenjiro Adachi, Guangming Wu, Styliani Galatidou, Jianhua Li, Hans R. Schöler, Sebastian A. Leidel, Ivan Bedzhov
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19353-0
id doaj-8ca51a4f837f4e888adc4dfe1fda8fa3
record_format Article
spelling doaj-8ca51a4f837f4e888adc4dfe1fda8fa32021-05-11T09:04:52ZengNature Publishing GroupNature Communications2041-17232020-10-0111111710.1038/s41467-020-19353-0Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapauseRui Fan0Yung Su Kim1Jie Wu2Rui Chen3Dagmar Zeuschner4Karina Mildner5Kenjiro Adachi6Guangming Wu7Styliani Galatidou8Jianhua Li9Hans R. Schöler10Sebastian A. Leidel11Ivan Bedzhov12Embryonic Self-Organization research group, Max Planck Institute for Molecular BiomedicineEmbryonic Self-Organization research group, Max Planck Institute for Molecular BiomedicineUniversity of Bern, Department of Chemistry and BiochemistryEmbryonic Self-Organization research group, Max Planck Institute for Molecular BiomedicineElectron Microscopy Unit, Max Planck Institute for Molecular BiomedicineElectron Microscopy Unit, Max Planck Institute for Molecular BiomedicineDepartment for Cell and Developmental Biology, Max Planck Institute for Molecular BiomedicineDepartment for Cell and Developmental Biology, Max Planck Institute for Molecular BiomedicineEmbryonic Self-Organization research group, Max Planck Institute for Molecular BiomedicineEmbryonic Self-Organization research group, Max Planck Institute for Molecular BiomedicineDepartment for Cell and Developmental Biology, Max Planck Institute for Molecular BiomedicineUniversity of Bern, Department of Chemistry and BiochemistryEmbryonic Self-Organization research group, Max Planck Institute for Molecular BiomedicineEmbryonic diapause is a state of dormancy with poorly understood mechanisms of embryo intrinsic regulation. Here, the authors show that murine diapause is a dynamic process, where tissue-scale reorganization of the pluripotent lineage is controlled in an autocrine manner by the Wnt/b-catenin/Esrrb signalling cascade.https://doi.org/10.1038/s41467-020-19353-0
collection DOAJ
language English
format Article
sources DOAJ
author Rui Fan
Yung Su Kim
Jie Wu
Rui Chen
Dagmar Zeuschner
Karina Mildner
Kenjiro Adachi
Guangming Wu
Styliani Galatidou
Jianhua Li
Hans R. Schöler
Sebastian A. Leidel
Ivan Bedzhov
spellingShingle Rui Fan
Yung Su Kim
Jie Wu
Rui Chen
Dagmar Zeuschner
Karina Mildner
Kenjiro Adachi
Guangming Wu
Styliani Galatidou
Jianhua Li
Hans R. Schöler
Sebastian A. Leidel
Ivan Bedzhov
Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause
Nature Communications
author_facet Rui Fan
Yung Su Kim
Jie Wu
Rui Chen
Dagmar Zeuschner
Karina Mildner
Kenjiro Adachi
Guangming Wu
Styliani Galatidou
Jianhua Li
Hans R. Schöler
Sebastian A. Leidel
Ivan Bedzhov
author_sort Rui Fan
title Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause
title_short Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause
title_full Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause
title_fullStr Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause
title_full_unstemmed Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause
title_sort wnt/beta-catenin/esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-10-01
description Embryonic diapause is a state of dormancy with poorly understood mechanisms of embryo intrinsic regulation. Here, the authors show that murine diapause is a dynamic process, where tissue-scale reorganization of the pluripotent lineage is controlled in an autocrine manner by the Wnt/b-catenin/Esrrb signalling cascade.
url https://doi.org/10.1038/s41467-020-19353-0
work_keys_str_mv AT ruifan wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
AT yungsukim wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
AT jiewu wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
AT ruichen wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
AT dagmarzeuschner wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
AT karinamildner wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
AT kenjiroadachi wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
AT guangmingwu wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
AT stylianigalatidou wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
AT jianhuali wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
AT hansrscholer wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
AT sebastianaleidel wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
AT ivanbedzhov wntbetacateninesrrbsignallingcontrolsthetissuescalereorganizationandmaintenanceofthepluripotentlineageduringmurineembryonicdiapause
_version_ 1721450223842099200

Similar Items