Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation

Plexins are the receptors for the guidance molecules semaphorins and regulate immunity and the development of the nervous and cardiovascular systems. Here authors present a structure of full-length human PlexinC1 in complex with its ligand A39R, which reveals how inter-domain interactions couple ext...

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Main Authors:	Yi-Chun Kuo, Hua Chen, Guijun Shang, Emiko Uchikawa, Hui Tian, Xiao-Chen Bai, Xuewu Zhang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15862-0

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spelling	doaj-8ca1c43a536c46318a1ddd5ba7d60d012021-05-11T09:07:42ZengNature Publishing GroupNature Communications2041-17232020-04-0111111210.1038/s41467-020-15862-0Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activationYi-Chun Kuo0Hua Chen1Guijun Shang2Emiko Uchikawa3Hui Tian4Xiao-Chen Bai5Xuewu Zhang6Department of Pharmacology, University of Texas Southwestern Medical CenterDepartment of Pharmacology, University of Texas Southwestern Medical CenterDepartment of Pharmacology, University of Texas Southwestern Medical CenterDepartment of Biophysics, University of Texas Southwestern Medical CenterDepartment of Pharmacology, University of Texas Southwestern Medical CenterDepartment of Biophysics, University of Texas Southwestern Medical CenterDepartment of Pharmacology, University of Texas Southwestern Medical CenterPlexins are the receptors for the guidance molecules semaphorins and regulate immunity and the development of the nervous and cardiovascular systems. Here authors present a structure of full-length human PlexinC1 in complex with its ligand A39R, which reveals how inter-domain interactions couple extracellular ligand binding to receptor activation and signaling.https://doi.org/10.1038/s41467-020-15862-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yi-Chun Kuo Hua Chen Guijun Shang Emiko Uchikawa Hui Tian Xiao-Chen Bai Xuewu Zhang
spellingShingle	Yi-Chun Kuo Hua Chen Guijun Shang Emiko Uchikawa Hui Tian Xiao-Chen Bai Xuewu Zhang Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation Nature Communications
author_facet	Yi-Chun Kuo Hua Chen Guijun Shang Emiko Uchikawa Hui Tian Xiao-Chen Bai Xuewu Zhang
author_sort	Yi-Chun Kuo
title	Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation
title_short	Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation
title_full	Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation
title_fullStr	Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation
title_full_unstemmed	Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation
title_sort	cryo-em structure of the plexinc1/a39r complex reveals inter-domain interactions critical for ligand-induced activation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-04-01
description	Plexins are the receptors for the guidance molecules semaphorins and regulate immunity and the development of the nervous and cardiovascular systems. Here authors present a structure of full-length human PlexinC1 in complex with its ligand A39R, which reveals how inter-domain interactions couple extracellular ligand binding to receptor activation and signaling.
url	https://doi.org/10.1038/s41467-020-15862-0
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Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation

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