Immune Cell Hacking: Challenges and Clinical Approaches to Create Smarter Generations of Chimeric Antigen Receptor T Cells

Immune Cell Hacking: Challenges and Clinical Approaches to Create Smarter Generations of Chimeric Antigen Receptor T Cells

T cells equipped with chimeric antigen receptors (CAR T cells) have recently provided promising advances as a novel immunotherapeutic approach for cancer treatment. CAR T cell therapy has shown stunning results especially in B-cell malignancies; however, it has shown less success against solid tumor...

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Bibliographic Details
Main Authors: Reza Elahi, Elnaz Khosh, Safa Tahmasebi, Abdolreza Esmaeilzadeh
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
adoptive cell therapy
chimeric antigen receptor T cell therapy
immunotherapy
clinical applications
immune cell hacking
challenges
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01717/full

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