Application of an Inter-Species Extrapolation Method for the Prediction of Drug Interactions between Propolis and Duloxetine in Humans

Application of an Inter-Species Extrapolation Method for the Prediction of Drug Interactions between Propolis and Duloxetine in Humans

Duloxetine (DLX) is a potent drug investigated for the treatment of depression and urinary incontinence. DLX is extensively metabolized in the liver by two P450 isozymes, CYP2D6 and CYP1A2. Propolis (PPL) is one of the popular functional foods known to have effects on activities of CYPs, including C...

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Bibliographic Details
Main Authors: Thi Lien Ngo, Chung-Hee Lee, Nayoung Han, Hyun-Moon Back, Su-Jin Rhee, Keumhan Noh, Hwi-Yeol Yun, Wonku Kang, Jung-Woo Chae
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
duloxetine
propolis
drug interaction
extrapolation
cyp1a2
Online Access:https://www.mdpi.com/1422-0067/21/5/1862

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https://www.mdpi.com/1422-0067/21/5/1862

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