Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data
The apparent clustering of human cases of influenza A (H5N1) among blood relatives has been considered as evidence of genetic variation in susceptibility. We show that, by chance alone, a high proportion of clusters are expected to be limited to blood relatives when infection is a rare event.
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2007-07-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/13/7/06-1538_article |
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doaj-8c97b276800f429aa1f555f970fea2b12020-11-25T02:34:00ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592007-07-011371074107410.3201/eid1307.061538Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering DataVirginia E. PitzerSonja J. OlsenCarl T. BergstromScott F. DowellMarc LipsitchThe apparent clustering of human cases of influenza A (H5N1) among blood relatives has been considered as evidence of genetic variation in susceptibility. We show that, by chance alone, a high proportion of clusters are expected to be limited to blood relatives when infection is a rare event.https://wwwnc.cdc.gov/eid/article/13/7/06-1538_articleavian influenzagenetic susceptibilitymodels, binomialdisease clustering, dispatch |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Virginia E. Pitzer Sonja J. Olsen Carl T. Bergstrom Scott F. Dowell Marc Lipsitch |
| spellingShingle |
Virginia E. Pitzer Sonja J. Olsen Carl T. Bergstrom Scott F. Dowell Marc Lipsitch Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data Emerging Infectious Diseases avian influenza genetic susceptibility models, binomial disease clustering, dispatch |
| author_facet |
Virginia E. Pitzer Sonja J. Olsen Carl T. Bergstrom Scott F. Dowell Marc Lipsitch |
| author_sort |
Virginia E. Pitzer |
| title |
Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data |
| title_short |
Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data |
| title_full |
Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data |
| title_fullStr |
Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data |
| title_full_unstemmed |
Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data |
| title_sort |
little evidence for genetic susceptibility to influenza a (h5n1) from family clustering data |
| publisher |
Centers for Disease Control and Prevention |
| series |
Emerging Infectious Diseases |
| issn |
1080-6040 1080-6059 |
| publishDate |
2007-07-01 |
| description |
The apparent clustering of human cases of influenza A (H5N1) among blood relatives has been considered as evidence of genetic variation in susceptibility. We show that, by chance alone, a high proportion of clusters are expected to be limited to blood relatives when infection is a rare event. |
| topic |
avian influenza genetic susceptibility models, binomial disease clustering, dispatch |
| url |
https://wwwnc.cdc.gov/eid/article/13/7/06-1538_article |
| work_keys_str_mv |
AT virginiaepitzer littleevidenceforgeneticsusceptibilitytoinfluenzaah5n1fromfamilyclusteringdata AT sonjajolsen littleevidenceforgeneticsusceptibilitytoinfluenzaah5n1fromfamilyclusteringdata AT carltbergstrom littleevidenceforgeneticsusceptibilitytoinfluenzaah5n1fromfamilyclusteringdata AT scottfdowell littleevidenceforgeneticsusceptibilitytoinfluenzaah5n1fromfamilyclusteringdata AT marclipsitch littleevidenceforgeneticsusceptibilitytoinfluenzaah5n1fromfamilyclusteringdata |
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