Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data

Little Evidence for Genetic Susceptibility to Influenza A (H5N1) from Family Clustering Data

The apparent clustering of human cases of influenza A (H5N1) among blood relatives has been considered as evidence of genetic variation in susceptibility. We show that, by chance alone, a high proportion of clusters are expected to be limited to blood relatives when infection is a rare event.

Bibliographic Details
Main Authors: Virginia E. Pitzer, Sonja J. Olsen, Carl T. Bergstrom, Scott F. Dowell, Marc Lipsitch
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2007-07-01
Series:Emerging Infectious Diseases
Subjects:
avian influenza
genetic susceptibility
models, binomial
disease clustering, dispatch
Online Access:https://wwwnc.cdc.gov/eid/article/13/7/06-1538_article
Description
Summary:The apparent clustering of human cases of influenza A (H5N1) among blood relatives has been considered as evidence of genetic variation in susceptibility. We show that, by chance alone, a high proportion of clusters are expected to be limited to blood relatives when infection is a rare event.
ISSN:1080-6040
1080-6059

Similar Items