Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation

Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation

Abstract Background Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to Endoplasmic Reticulum (ER) stress often associated to autophagy deregulat...

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Bibliographic Details
Main Authors: Luigi Mele, Marcella la Noce, Francesca Paino, Tarik Regad, Sarah Wagner, Davide Liccardo, Gianpaolo Papaccio, Angela Lombardi, Michele Caraglia, Virginia Tirino, Vincenzo Desiderio, Federica Papaccio
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pentose phosphate pathway
Autophagy
Lapatinib
ER stress
TKI
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s13046-019-1164-5

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