Androgen regulation of 5α-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention.

Androgen regulation of 5α-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention.

The enzyme 5α-reductase, which converts testosterone to dihydrotestosterone (DHT), performs key functions in the androgen receptor (AR) signaling pathway. The three isoenzymes of 5α-reductase identified to date are encoded by different genes: SRD5A1, SRD5A2, and SRD5A3. In this study, we investigate...

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Bibliographic Details
Main Authors: Jin Li, Zhiyong Ding, Zhengxin Wang, Jing-Fang Lu, Sankar N Maity, Nora M Navone, Christopher J Logothetis, Gordon B Mills, Jeri Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3237548?pdf=render

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