One-pot synthesis of polyhydropyridine derivatives via Hantzsch four component condensation in water medium: Use of a recyclable Lewis acid [Ce(SO4)2.4H2O] catalyst

An efficient and eco-friendly method for the synthesis of polyhydroquinoline derivatives using Ce(SO4)2.4H2O as mild and heterogeneous Lewis acid catalyst via the Hantzsch reaction in very short reaction time is reported. A mixture...

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Main Authors:	Elaheh Mosaddegh, Asadollah Hassankhani
Format:	Article
Language:	English
Published:	Chemical Society of Ethiopia 2012-12-01
Series:	Bulletin of the Chemical Society of Ethiopia
Subjects:	Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O Polyhydroquinoline Hantzsch reaction Muticomponent reaction Dihydropyridine
Online Access:	http://www.ajol.info/index.php/bcse/article/view/80288

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spelling	doaj-8c8cf09a639344428c738ba5f77dc4ba2020-11-24T21:10:51ZengChemical Society of EthiopiaBulletin of the Chemical Society of Ethiopia1011-39241726-801X2012-12-01263461465One-pot synthesis of polyhydropyridine derivatives via Hantzsch four component condensation in water medium: Use of a recyclable Lewis acid [Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O] catalystElaheh MosaddeghAsadollah HassankhaniAn efficient and eco-friendly method for the synthesis of polyhydroquinoline derivatives using Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O as mild and heterogeneous Lewis acid catalyst via the Hantzsch reaction in very short reaction time is reported. A mixture of an appropriate aldehyde, dimedone, ethyl acetoacetate and malononitrile in the presence of the Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O at reflux conditions in water based media resulted in good to excellent yields of the corresponding products. The catalyst can be used as selective for some aromatic aldehydes in the reaction conditions.DOI: http://dx.doi.org/10.4314/bcse.v26i3.16http://www.ajol.info/index.php/bcse/article/view/80288Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>OPolyhydroquinolineHantzsch reactionMuticomponent reactionDihydropyridine
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Elaheh Mosaddegh Asadollah Hassankhani
spellingShingle	Elaheh Mosaddegh Asadollah Hassankhani One-pot synthesis of polyhydropyridine derivatives via Hantzsch four component condensation in water medium: Use of a recyclable Lewis acid [Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O] catalyst Bulletin of the Chemical Society of Ethiopia Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O Polyhydroquinoline Hantzsch reaction Muticomponent reaction Dihydropyridine
author_facet	Elaheh Mosaddegh Asadollah Hassankhani
author_sort	Elaheh Mosaddegh
title	One-pot synthesis of polyhydropyridine derivatives via Hantzsch four component condensation in water medium: Use of a recyclable Lewis acid [Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O] catalyst
title_short	One-pot synthesis of polyhydropyridine derivatives via Hantzsch four component condensation in water medium: Use of a recyclable Lewis acid [Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O] catalyst
title_full	One-pot synthesis of polyhydropyridine derivatives via Hantzsch four component condensation in water medium: Use of a recyclable Lewis acid [Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O] catalyst
title_fullStr	One-pot synthesis of polyhydropyridine derivatives via Hantzsch four component condensation in water medium: Use of a recyclable Lewis acid [Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O] catalyst
title_full_unstemmed	One-pot synthesis of polyhydropyridine derivatives via Hantzsch four component condensation in water medium: Use of a recyclable Lewis acid [Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O] catalyst
title_sort	one-pot synthesis of polyhydropyridine derivatives via hantzsch four component condensation in water medium: use of a recyclable lewis acid [ce(so<sub>4</sub>)<sub>2</sub>.4h<sub>2</sub>o] catalyst
publisher	Chemical Society of Ethiopia
series	Bulletin of the Chemical Society of Ethiopia
issn	1011-3924 1726-801X
publishDate	2012-12-01
description	An efficient and eco-friendly method for the synthesis of polyhydroquinoline derivatives using Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O as mild and heterogeneous Lewis acid catalyst via the Hantzsch reaction in very short reaction time is reported. A mixture of an appropriate aldehyde, dimedone, ethyl acetoacetate and malononitrile in the presence of the Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O at reflux conditions in water based media resulted in good to excellent yields of the corresponding products. The catalyst can be used as selective for some aromatic aldehydes in the reaction conditions.DOI: http://dx.doi.org/10.4314/bcse.v26i3.16
topic	Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O Polyhydroquinoline Hantzsch reaction Muticomponent reaction Dihydropyridine
url	http://www.ajol.info/index.php/bcse/article/view/80288
work_keys_str_mv	AT elahehmosaddegh onepotsynthesisofpolyhydropyridinederivativesviahantzschfourcomponentcondensationinwatermediumuseofarecyclablelewisacidcesosub4subsub2sub4hsub2subocatalyst AT asadollahhassankhani onepotsynthesisofpolyhydropyridinederivativesviahantzschfourcomponentcondensationinwatermediumuseofarecyclablelewisacidcesosub4subsub2sub4hsub2subocatalyst
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One-pot synthesis of polyhydropyridine derivatives via Hantzsch four component condensation in water medium: Use of a recyclable Lewis acid [Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O] catalyst

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