P2X7 Receptor Antagonism Attenuates the Intermittent Hypoxia-induced Spatial Deficits in a Murine Model of Sleep Apnea Via Inhibiting Neuroinflammation and Oxidative Stress

P2X7 Receptor Antagonism Attenuates the Intermittent Hypoxia-induced Spatial Deficits in a Murine Model of Sleep Apnea Via Inhibiting Neuroinflammation and Oxidative Stress

Background: The mechanism of the neural injury caused by chronic intermittent hypoxia (CIH) that characterizes obstructive sleep apnea syndrome (OSAS) is not clearly known. The purpose of this study was to investigate whether P2X7 receptor (P2X7R) is responsible for the CIH-induced neural injury and...

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Bibliographic Details
Main Authors: Yan Deng, Xue-Ling Guo, Xiao Yuan, Jin Shang, Die Zhu, Hui-Guo Liu
Format: Article
Language:English
Published: Wolters Kluwer 2015-01-01
Series:Chinese Medical Journal
Subjects:
Inflammation; Intermittent Hypoxia; Oxidative Stress; P2X7 Receptor; Sleep Apnea
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=16;spage=2168;epage=2175;aulast=Deng

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