Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury

The effects of cyclophosphamide on 5-hydroxytryptamine (5-HT) synthesis in the intestinal tissue of rats were investigated. Rats received 120 mg/kg cyclophosphamide intraperitoneally as a single administration, and kaolin and food intake was measured by an automatic monitoring apparatus. Ileal tissu...

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Bibliographic Details
Main Authors: Akihisa Kamiya, Takuji Machida, Megumi Hirano, Maiko Machida, Saki Shiga, Naoya Hamaue, Masahiko Hirafuji, Kenji Iizuka
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Journal of Pharmacological Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000748