Scintillating fiber based in-vivo dose monitoring system to the rectum in proton therapy of prostate cancer: A Geant4 Monte Carlo simulation

<p><strong>Purpose: </strong>To construct a dose monitoring system based on an endorectal balloon coupled to thin scintillating fibers to study the dose to the rectum in proton therapy of prostate cancer.</p><p><strong>Method:</strong> A Geant4 Monte Carlo t...

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Main Authors: Biniam Yohannes Tesfamicael, Steven Avery, Paul Gueye, Don Lyons, Mahadevappa Mahesh
Format: Article
Language:English
Published: IJCTO 2014-03-01
Series:International Journal of Cancer Therapy and Oncology
Subjects:
Online Access:http://ijcto.org/index.php/IJCTO/article/view/76
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spelling doaj-8c73ee835b5349768c1fb4f6df8d647a2020-11-24T21:03:00ZengIJCTOInternational Journal of Cancer Therapy and Oncology 2330-40492014-03-012210.14319/ijcto.0202.446Scintillating fiber based in-vivo dose monitoring system to the rectum in proton therapy of prostate cancer: A Geant4 Monte Carlo simulationBiniam Yohannes Tesfamicael0Steven Avery1Paul Gueye2Don Lyons3Mahadevappa Mahesh4Department of Physics, Hampton University, Hampton, VirginiaDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PennsylvaniaDepartment of Physics, Hampton University, Hampton, VirginiaDepartment of Physics, Hampton University, Hampton, VirginiaDeparment of Radiology and Radiological Sciences, John Hopkins University, Baltimore, Maryland<p><strong>Purpose: </strong>To construct a dose monitoring system based on an endorectal balloon coupled to thin scintillating fibers to study the dose to the rectum in proton therapy of prostate cancer.</p><p><strong>Method:</strong> A Geant4 Monte Carlo toolkit was used to simulate the proton therapy of prostate cancer, with an endorectal balloon and a set of scintillating fibers for immobilization and dosimetry measurements, respectively.</p><p><strong>Results: </strong>A linear response of the fibers to the dose delivered was observed to within less than 2%. Results obtained show that fibers close to the prostate recorded higher dose, with the closest fiber recording about one-third of the dose to the target. A 1/r<sup>2</sup> (r is defined as center-to-center distance between the prostate and the fibers) decrease was observed as one goes toward the frontal and distal regions. A very low dose was recorded by the fibers beneath the balloon which is a clear indication that the overall volume of the rectal wall that is exposed to a higher dose is relatively minimized. Further analysis showed a relatively linear relationship between the dose to the target and the dose to the top fibers (total 17), with a slope of (-0.07 ± 0.07) at large number of events per degree of rotation of the modulator wheel (i.e., dose).</p><p><strong>Conclusion:</strong> Thin (1 mm × 1 mm), long (1 m) scintillating fibers were found to be ideal for real time in-vivo dose measurement to the rectum during proton therapy of prostate cancer. The linear response of the fibers to the dose delivered makes them good candidates as dosimeters. With thorough calibration and the ability to define a good correlation between the dose to the target and the dose to the fibers, such dosimeters can be used for real time dose verification to the target.</p><p>-----------------------------------</p><p><strong>Cite this article as</strong>: Tesfamicael BY, Avery S, Gueye P, Lyons D, Mahesh M. Scintillating fiber based in-vivo dose monitoring system to the rectum in proton therapy of prostate cancer: A Geant4 Monte Carlo simulation. <em>Int J Cancer Ther Oncol</em> 2014; <strong>2</strong>(2):02024.</p><p><strong>DOI:</strong> <a href="http://dx.doi.org/10.14319/ijcto.0202.4">http://dx.doi.org/10.14319/ijcto.0202.4</a></p>http://ijcto.org/index.php/IJCTO/article/view/76Prostate CancerProton therapyEndorectal BalloonScintillating FibersGeant4 Monte CarloRectal WallHadron Therapy
collection DOAJ
language English
format Article
sources DOAJ
author Biniam Yohannes Tesfamicael
Steven Avery
Paul Gueye
Don Lyons
Mahadevappa Mahesh
spellingShingle Biniam Yohannes Tesfamicael
Steven Avery
Paul Gueye
Don Lyons
Mahadevappa Mahesh
Scintillating fiber based in-vivo dose monitoring system to the rectum in proton therapy of prostate cancer: A Geant4 Monte Carlo simulation
International Journal of Cancer Therapy and Oncology
Prostate Cancer
Proton therapy
Endorectal Balloon
Scintillating Fibers
Geant4 Monte Carlo
Rectal Wall
Hadron Therapy
author_facet Biniam Yohannes Tesfamicael
Steven Avery
Paul Gueye
Don Lyons
Mahadevappa Mahesh
author_sort Biniam Yohannes Tesfamicael
title Scintillating fiber based in-vivo dose monitoring system to the rectum in proton therapy of prostate cancer: A Geant4 Monte Carlo simulation
title_short Scintillating fiber based in-vivo dose monitoring system to the rectum in proton therapy of prostate cancer: A Geant4 Monte Carlo simulation
title_full Scintillating fiber based in-vivo dose monitoring system to the rectum in proton therapy of prostate cancer: A Geant4 Monte Carlo simulation
title_fullStr Scintillating fiber based in-vivo dose monitoring system to the rectum in proton therapy of prostate cancer: A Geant4 Monte Carlo simulation
title_full_unstemmed Scintillating fiber based in-vivo dose monitoring system to the rectum in proton therapy of prostate cancer: A Geant4 Monte Carlo simulation
title_sort scintillating fiber based in-vivo dose monitoring system to the rectum in proton therapy of prostate cancer: a geant4 monte carlo simulation
publisher IJCTO
series International Journal of Cancer Therapy and Oncology
issn 2330-4049
publishDate 2014-03-01
description <p><strong>Purpose: </strong>To construct a dose monitoring system based on an endorectal balloon coupled to thin scintillating fibers to study the dose to the rectum in proton therapy of prostate cancer.</p><p><strong>Method:</strong> A Geant4 Monte Carlo toolkit was used to simulate the proton therapy of prostate cancer, with an endorectal balloon and a set of scintillating fibers for immobilization and dosimetry measurements, respectively.</p><p><strong>Results: </strong>A linear response of the fibers to the dose delivered was observed to within less than 2%. Results obtained show that fibers close to the prostate recorded higher dose, with the closest fiber recording about one-third of the dose to the target. A 1/r<sup>2</sup> (r is defined as center-to-center distance between the prostate and the fibers) decrease was observed as one goes toward the frontal and distal regions. A very low dose was recorded by the fibers beneath the balloon which is a clear indication that the overall volume of the rectal wall that is exposed to a higher dose is relatively minimized. Further analysis showed a relatively linear relationship between the dose to the target and the dose to the top fibers (total 17), with a slope of (-0.07 ± 0.07) at large number of events per degree of rotation of the modulator wheel (i.e., dose).</p><p><strong>Conclusion:</strong> Thin (1 mm × 1 mm), long (1 m) scintillating fibers were found to be ideal for real time in-vivo dose measurement to the rectum during proton therapy of prostate cancer. The linear response of the fibers to the dose delivered makes them good candidates as dosimeters. With thorough calibration and the ability to define a good correlation between the dose to the target and the dose to the fibers, such dosimeters can be used for real time dose verification to the target.</p><p>-----------------------------------</p><p><strong>Cite this article as</strong>: Tesfamicael BY, Avery S, Gueye P, Lyons D, Mahesh M. Scintillating fiber based in-vivo dose monitoring system to the rectum in proton therapy of prostate cancer: A Geant4 Monte Carlo simulation. <em>Int J Cancer Ther Oncol</em> 2014; <strong>2</strong>(2):02024.</p><p><strong>DOI:</strong> <a href="http://dx.doi.org/10.14319/ijcto.0202.4">http://dx.doi.org/10.14319/ijcto.0202.4</a></p>
topic Prostate Cancer
Proton therapy
Endorectal Balloon
Scintillating Fibers
Geant4 Monte Carlo
Rectal Wall
Hadron Therapy
url http://ijcto.org/index.php/IJCTO/article/view/76
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