Pharmacological inhibition of the PI3K/PTEN/Akt and mTOR signalling pathways limits follicle activation induced by ovarian cryopreservation and in vitro culture

Pharmacological inhibition of the PI3K/PTEN/Akt and mTOR signalling pathways limits follicle activation induced by ovarian cryopreservation and in vitro culture

Abstract Background Cryopreservation and transplantation of ovarian tissue (OTCTP) represent a promising fertility preservation technique for prepubertal patients or for patients requiring urgent oncological management. However, a major obstacle of this technique is follicle loss due to, among other...

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Bibliographic Details
Main Authors: Carmen Terren, Michelle Nisolle, Carine Munaut
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Ovarian Research
Subjects:
Fertility preservation
Cryopreservation
Transplantation
Follicular activation
Primordial follicles
Signalling pathways
Online Access:https://doi.org/10.1186/s13048-021-00846-5

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