The left ventricle undergoes biomechanical and gene expression changes in response to increased right ventricular pressure overload

The left ventricle undergoes biomechanical and gene expression changes in response to increased right ventricular pressure overload

Abstract Pulmonary hypertension (PH) results in right ventricular (RV) pressure overload and eventual failure. Current research efforts have focused on the RV while overlooking the left ventricle (LV), which is responsible for mechanically assisting the RV during contraction. The objective of this s...

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Bibliographic Details
Main Authors: Vitaly O. Kheyfets, Melanie J. Dufva, Mario Boehm, Xuefeit Tian, Xulei Qin, Jennifer E. Tabakh, Uyen Truong, Dunbar Ivy, Edda Spiekerkoetter
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:Physiological Reports
Subjects:
interventricular coupling
left ventricle
pulmonary hypertension
right ventricle
Online Access:https://doi.org/10.14814/phy2.14347

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