Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages

Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages

Abstract Tumor‐associated macrophages (TAMs) promote tumor growth and metastasis by suppressing tumor immune surveillance. Herein, we provide evidence that the immunosuppressive phenotype of TAMs is controlled by long‐chain fatty acid metabolism, specifically unsaturated fatty acids, here exemplifie...

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Bibliographic Details
Main Authors: Hao Wu, Yijie Han, Yasmina Rodriguez Sillke, Hongzhang Deng, Sophiya Siddiqui, Christoph Treese, Franziska Schmidt, Marie Friedrich, Jacqueline Keye, Jiajia Wan, Yue Qin, Anja A Kühl, Zhihai Qin, Britta Siegmund, Rainer Glauben
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:EMBO Molecular Medicine
Subjects:
cancer immunotherapy
lipid droplets
lipid metabolism
tumor microenvironment
tumor‐associated macrophage
Online Access:https://doi.org/10.15252/emmm.201910698

Internet

https://doi.org/10.15252/emmm.201910698

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