Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
The relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, facilitates migration and metastatic spread.
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05346-7 |