Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis

The relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, facilitates migration and metastatic spread.

Bibliographic Details
Main Authors:	Tamara Muliaditan, Jonathan Caron, Mary Okesola, James W. Opzoomer, Paris Kosti, Mirella Georgouli, Peter Gordon, Sharanpreet Lall, Desislava M. Kuzeva, Luisa Pedro, Jacqueline D. Shields, Cheryl E. Gillett, Sandra S. Diebold, Victoria Sanz-Moreno, Tony Ng, Esther Hoste, James N. Arnold
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05346-7

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spelling	doaj-8c66af37aaba412f826bf1e4aabd5fd72021-05-11T09:31:27ZengNature Publishing GroupNature Communications2041-17232018-07-019111510.1038/s41467-018-05346-7Macrophages are exploited from an innate wound healing response to facilitate cancer metastasisTamara Muliaditan0Jonathan Caron1Mary Okesola2James W. Opzoomer3Paris Kosti4Mirella Georgouli5Peter Gordon6Sharanpreet Lall7Desislava M. Kuzeva8Luisa Pedro9Jacqueline D. Shields10Cheryl E. Gillett11Sandra S. Diebold12Victoria Sanz-Moreno13Tony Ng14Esther Hoste15James N. Arnold16School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s CampusSchool of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s CampusSchool of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s CampusSchool of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s CampusSchool of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s CampusTumour Plasticity Laboratory, Randall Centre for Cell and Molecular Biophysics, King′s College London, Guy′s CampusSchool of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s CampusSchool of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s CampusSchool of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s CampusMedical Research Council Cancer Cell Unit, Hutchison/Medical Research Council Research CentreMedical Research Council Cancer Cell Unit, Hutchison/Medical Research Council Research CentreSchool of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s CampusNational Institute for Biological Standards and ControlTumour Plasticity Laboratory, Randall Centre for Cell and Molecular Biophysics, King′s College London, Guy′s CampusSchool of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s CampusUnit for Cellular and Molecular Pathophysiology, VIB Center for Inflammation ResearchSchool of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, Guy’s CampusThe relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, facilitates migration and metastatic spread.https://doi.org/10.1038/s41467-018-05346-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tamara Muliaditan Jonathan Caron Mary Okesola James W. Opzoomer Paris Kosti Mirella Georgouli Peter Gordon Sharanpreet Lall Desislava M. Kuzeva Luisa Pedro Jacqueline D. Shields Cheryl E. Gillett Sandra S. Diebold Victoria Sanz-Moreno Tony Ng Esther Hoste James N. Arnold
spellingShingle	Tamara Muliaditan Jonathan Caron Mary Okesola James W. Opzoomer Paris Kosti Mirella Georgouli Peter Gordon Sharanpreet Lall Desislava M. Kuzeva Luisa Pedro Jacqueline D. Shields Cheryl E. Gillett Sandra S. Diebold Victoria Sanz-Moreno Tony Ng Esther Hoste James N. Arnold Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis Nature Communications
author_facet	Tamara Muliaditan Jonathan Caron Mary Okesola James W. Opzoomer Paris Kosti Mirella Georgouli Peter Gordon Sharanpreet Lall Desislava M. Kuzeva Luisa Pedro Jacqueline D. Shields Cheryl E. Gillett Sandra S. Diebold Victoria Sanz-Moreno Tony Ng Esther Hoste James N. Arnold
author_sort	Tamara Muliaditan
title	Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
title_short	Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
title_full	Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
title_fullStr	Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
title_full_unstemmed	Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
title_sort	macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-07-01
description	The relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, facilitates migration and metastatic spread.
url	https://doi.org/10.1038/s41467-018-05346-7
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Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis

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