Epidemiology of chronic renal disease in the Northwest of Russia: setting-up the register

• Main Authors: V A Dobronravov, A V Smirnov, S V Dragunov, R V Zverkov, T V Evdokimova, S Sh Butrimova, V I Grigorschuk
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2004-09-01
• Series: Терапевтический архив
• Subjects: chronic renal disease; chronic renal failure; epidemiology; prevalence; morbidity; survival; replacement renal therapy
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/29911
• ISSN: 0040-3660; 2309-5342

Aim. To study epoidemiology of chronic renal disease (CRD) in the North-West region of the Russian Federation. Material and methods. A population retrospective trial was performed from 01.07.98 to 30.06.99 in the Vologda region, towns Veliky Novgorod and Syktyvkar (total population 1840000). 490 cases of chronic renal failure (CRF) with creatinin levels > 300 mcmol/l corresponding to CRD stage IV and V by glomerular filtration rate were detected. CRD stage IV-V prevalence, morbidity including sexand age-specific parameters, cumulative survival in different etiology of CRD regarding replacement therapy (RT) and nephrologist supervision were estimated. Results. Mean prevalence and morbidity were 266 and 108 cases per million. Number of affected males and females was the same. CRD was provoked by chronic glomerulonephritis (CGN) - 41%, chronic interstitional nephritis - 16%, diabetes mellitus - 14%, renal polycystic disease - 8%, amyloidosis - 6%, hypertension nephrosclerosis - 2%, other causes - 3%, cases of unclear etiology 10%. Among patients with primary renal pathology on RT, number of CGN patients was higher 61% while diabetic and amyloidosis shares were much lower 1.6 and 0.8%. 31.1% patients given no RT had Cr > 500 mcmol/l and glomerular filtration rate < 10 ml/min. Incidence of CRD stage IV- V in RT patients was 80 per million, 8 patients per million for I year started RT for the first time. CRF mortality was 85 patients per million a year. 88.4% of deaths in patients given no RT was due to uremia. Cumulative survival for RT patients and RT untreated was 90 and 50% a year, respectively. Survival of the RT untreated observed by the nephrologist was significantly higher (p = 0.003). Conclusion. New cases of CRD stage IV- V were comparable in number to European incidence rate while prevalence was much less because of lower number of old patients and RT treated. The problem of CRD treatment is urgent for RF and requires updating nephrological service and development ofRT programs.