Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity.

Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity.

<h4>Background</h4>The Ca(v)beta subunits of high voltage-activated Ca(2+) channels control the trafficking and biophysical properties of the alpha(1) subunit. The Ca(v)beta-alpha(1) interaction site has been mapped by crystallographic studies. Nevertheless, how this interaction leads to...

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Bibliographic Details
Main Authors: Iuliia Vitko, Aleksandr Shcheglovitov, Joel P Baumgart, Imilla I Arias-Olguín, Janet Murbartián, Juan Manuel Arias, Edward Perez-Reyes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18958281/?tool=EBI

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