CD103 (αE Integrin) Undergoes Endosomal Trafficking in Human Dendritic Cells, but Does Not Mediate Epithelial Adhesion

CD103 (αE Integrin) Undergoes Endosomal Trafficking in Human Dendritic Cells, but Does Not Mediate Epithelial Adhesion

Dendritic cell (DC) expression of CD103, the α subunit of αEβ7 integrin, is thought to enable DC interactions with E-cadherin-expressing gastrointestinal epithelia for improved mucosal immunosurveillance. In the stomach, efficient DC surveillance of the epithelial barrier is crucial for the inductio...

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Bibliographic Details
Main Authors: Steve Swain, Mandi M. Roe, Thomas A. Sebrell, Barkan Sidar, Jennifer Dankoff, Rachel VanAusdol, Lesley E. Smythies, Phillip D. Smith, Diane Bimczok
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
gastrointestinal epithelium
integrin alpha E
antigen-presenting cell
cell adhesion
endosome
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02989/full

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