The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation

The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation

Applying pre-steady state kinetics to an Escherichia-coli-based reconstituted translation system, we have studied how the antibiotic viomycin affects the accuracy of genetic code reading. We find that viomycin binds to translating ribosomes associated with a ternary complex (TC) consisting of elonga...

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Bibliographic Details
Main Authors: Mikael Holm, Chandra Sekhar Mandava, Måns Ehrenberg, Suparna Sanyal
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
ribosome
protein synthesis
translation
antibiotic
viomycin
Online Access:https://elifesciences.org/articles/46124

Internet

https://elifesciences.org/articles/46124

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