miR-203 facilitates tumor growth and metastasis by targeting fibroblast growth factor 2 in breast cancer

• Main Authors: He S, Zhang G, Dong H, Ma M, Sun Q
• Format: Article
• Language: English
• Published: Dove Medical Press 2016-10-01
• Series: OncoTargets and Therapy
• Subjects: Breast cancer; miR-203; FGF2
• Online Access: https://www.dovepress.com/mir-203-facilitates-tumor-growth-and-metastasis-by-targeting-fibroblas-peer-reviewed-article-OTT

Shuqian He, Guihui Zhang, He Dong, Maoqiang Ma, Qing Sun Department of Pathology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong, People’s Republic of China Abstract: Breast cancer is the second leading cause of cancer mortality in women worldwide. Molecular therapy is needed to improve the outcome in patients with breast cancer. miR-203 participates in cancer cell proliferation, transformation, and apoptosis. This study showed that miR-203 was upregulated in breast cancer tissues and the MCF-7 cell line. miR-203 knockdown suppressed colony formation and transformation and also limited migration in MCF-7 cells. Fibroblast growth factor 2 (FGF2) was confirmed as a novel target of miR-203, as miR-203 knockdown induced an enhanced expression of FGF2 in MCF-7 cells. Moreover, FGF2 can reverse transforming growth factor-β signal pathway to suppress breast cancer. These findings provide new insights with potential therapeutic applications for the treatment of breast cancer. Keywords: breast cancer, miR-203, FGF2