Local Packing Density Is the Main Structural Determinant of the Rate of Protein Sequence Evolution at Site Level

Local Packing Density Is the Main Structural Determinant of the Rate of Protein Sequence Evolution at Site Level

Functional and biophysical constraints result in site-dependent patterns of protein sequence variability. It is commonly assumed that the key structural determinant of site-specific rates of evolution is the Relative Solvent Accessibility (RSA). However, a recent study found that amino acid substitu...

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Bibliographic Details
Main Authors: So-Wei Yeh, Tsun-Tsao Huang, Jen-Wei Liu, Sung-Huan Yu, Chien-Hua Shih, Jenn-Kang Hwang, Julian Echave
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/572409

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