Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway

Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway

Chronic hyperglycemia increases apoptosis and reduces glucose-stimulated insulin secretion. Although protective agents have been searched extensively, none has been found so far. Here we tested FLZ, a synthetic derivative of squamosamide from a Chinese herb, as a potential candidate for antiglucotox...

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Bibliographic Details
Main Authors:	Xiangchen Kong, Longmei Zhang, Xianxin Hua, Xiaosong Ma
Format:	Article
Language:	English
Published:	Hindawi Limited 2015-01-01
Series:	Journal of Diabetes Research
Online Access:	http://dx.doi.org/10.1155/2015/803986

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