IL-12 Signaling Contributes to the Reprogramming of Neonatal CD8+ T Cells

IL-12 Signaling Contributes to the Reprogramming of Neonatal CD8+ T Cells

Neonates are highly susceptible to intracellular pathogens, leading to high morbidity and mortality rates. CD8+ T lymphocytes are responsible for the elimination of infected cells. Understanding the response of these cells to normal and high stimulatory conditions is important to propose better trea...

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Bibliographic Details
Main Authors: Darely Y. Gutiérrez-Reyna, Alejandra Cedillo-Baños, Linda A. Kempis-Calanis, Oscar Ramírez-Pliego, Lisa Bargier, Denis Puthier, Jose D. Abad-Flores, Morgane Thomas-Chollier, Denis Thieffry, Alejandra Medina-Rivera, Salvatore Spicuglia, Maria A. Santana
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
neonatal T cells
CD8+ T cells
RNA-sequencing
IL-12
T cell activation
neonatal immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01089/full

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