Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population

• Main Authors: Budai Barna, Balla Bernadett, Lakatos Péter L, Lazáry Áron, Horváth Henrik, Kósa János P, Hitre Erika, Bácsi Krisztián, Lakatos Péter, Speer Gábor
• Format: Article
• Language: English
• Published: BMC 2008-11-01
• Series: BMC Cancer
• Online Access: http://www.biomedcentral.com/1471-2407/8/317

<p>Abstract</p> <p>Background</p> <p>Epidemiological studies suggested the chemopreventive role of higher calcium intake in colorectal carcinogenesis. We examined genetic polymorphisms that might influence calcium metabolism: lactase (LCT) gene 13910 C/T polymorphism causing lactose intolerance and calcium-sensing receptor (CaSR) gene A986S polymorphism as a responsible factor for the altered cellular calcium sensation.</p> <p>Methods</p> <p>538 Hungarian subjects were studied: 278 patients with colorectal cancer and 260 healthy controls. Median follow-up was 17 months. After genotyping, the relationship between LCT 13910 C/T and CaSR A986S polymorphisms as well as tumor incidence/progression was investigated.</p> <p>Results</p> <p>in patient with colorectal cancer, a significantly higher LCT CC frequency was associated with increased distant disease recurrence (OR = 4.04; 95% CI = 1.71–9.58; p = 0.006). The disease free survival calculated from distant recurrence was reduced for those with LCT CC genotype (log rank test p = 0.008). In case of CaSR A986S polymorphism, the homozygous SS genotype was more frequent in patients than in controls (OR = 4.01; 95% CI = 1.33–12.07; p = 0.014). The number of LCT C and CaSR S risk alleles were correlated with tumor incidence (p = 0.035). The CCSS genotype combination was found only in patients with CRC (p = 0.033).</p> <p>Conclusion</p> <p>LCT 13910 C/T and CaSR A986S polymorphisms may have an impact on the progression and/or incidence of CRC.</p>