The evolution of dystonia-like movements in TOR1A rats after transient nerve injury is accompanied by dopaminergic dysregulation and abnormal oscillatory activity of a central motor network

The evolution of dystonia-like movements in TOR1A rats after transient nerve injury is accompanied by dopaminergic dysregulation and abnormal oscillatory activity of a central motor network

TOR1A is the most common inherited form of dystonia with still unclear pathophysiology and reduced penetrance of 30–40%. ∆ETorA rats mimic the TOR1A disease by expression of the human TOR1A mutation without presenting a dystonic phenotype. We aimed to induce dystonia-like symptoms in male ∆ETorA rat...

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Bibliographic Details
Main Authors: Susanne Knorr, Lisa Rauschenberger, Uri Ramirez Pasos, Maximilian U. Friedrich, Robert L. Peach, Kathrin Grundmann-Hauser, Thomas Ott, Aet O'Leary, Andreas Reif, Philip Tovote, Jens Volkmann, Chi Wang Ip
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neurobiology of Disease
Subjects:
DYT1
TOR1A
Two-hit hypothesis
Dopamine
LFP
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000863

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http://www.sciencedirect.com/science/article/pii/S0969996121000863

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