Experimental Verification of Gene Expression Related to Lung Cancer in Nasal Epitthelia

• Main Authors: Huang Qianwen, Qureshi Noman, Lin Simin, Duan Shaoyin
• Format: Article
• Language: English
• Published: EDP Sciences 2019-01-01
• Series: ITM Web of Conferences
• Online Access: https://www.itm-conferences.org/articles/itmconf/pdf/2019/03/itmconf_cset2019_02004.pdf

Genes expression related to lung cancer are observed in nasal epitthelia, to identify their similarities and differences and provide the basis for possible application. There are three groups:non-lung cancer group (NLC), lung cancer group (LC) and postoperative lung cancer group (PLC).The genes expression in nasal epitthelia were observed by PCR, including the HCK, NCF1, TLR8, EMR3, CSF2RB, DYSF, SPEF2, ANKFN1, HYDIN, DNAH5, C12orf55 and CCDC113. Their expression levels were obtained and statistically compared. Results showed that all the related genes in LC and PLC groups were highly expressed. There are significant difference in HCK, NCF1, TLR8, EMR3, CSF2RB and C12orf55 gene expression between the LC or PLC and NLC, and in EMR3 and C12orf55 between LC and PLC. Conclusions are HCK, NCF1, TLR8, EMR3, CSF2RB, C12orf55 can be used for lung cancer screening, while EMR3 and C12orf55 for the review of post-operative lung cancer.