THE RELATIONSHIP BETWEEN THE LEVEL OF SUPEROXIDDISMUTASE AND THE COEFFICIENT OF ENDOTHELIAL FUNCTION AT RESPIRATORY-CARDIAC COMORBIDITY

• Main Authors: O. S. Polunina, A. Kh. Akhmineeva, I. V. Sevostyanova, L. P. Voronina, E. A. Polunina
• Format: Article
• Language: Russian
• Published: Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” 2014-02-01
• Series: Кубанский научный медицинский вестник
• Subjects: хроническая обструктивная болезнь легких; ишемическая болезнь сердца; артериальная гипертензия; супероксиддисмутаза; эндотелиальная дисфункция; chronic obstructive pulmonary disease; ischemic heart disease; arterial hypertension; superoxiddismutase; endothelial dysfunction
• Online Access: https://ksma.elpub.ru/jour/article/view/36

In this work the correlation analysis between indicators of antioxidant protection (on activity of superoxiddismutase) and a functional condition of vascular endothelium at patients with respiratory-cardiac pathology is carried out. For estimation of a condition of vascular endothelium during the laser Doppler flowmetry added with ionoforetic tests, we calculated an coefficient of endothelial function. It is proved that ischemic heart disease accession at patients with chronic obstructive pulmonary disease significantly reduces activity of superoxiddismutase. It is also established that low activity of antioxidant protection at patients with a chronic obstructive pulmonary disease promotes damage of vessels by free radicals, causes dysfunction of endothelium, loading to progress of atherosclerosis and development of ischemic heart disease.