De Novo Fibrillary Glomerulonephritis (FGN) in a Renal Transplant with Chronic Hepatitis C

De Novo Fibrillary Glomerulonephritis (FGN) in a Renal Transplant with Chronic Hepatitis C

Chronic hepatitis C viremia (HepC) has been associated with numerous renal manifestations both in native kidneys and in the setting of renal transplantation. Glomerulonephritis (GN) of the renal allograft in the setting of HepC most commonly manifests as type 1 membranoproliferative GN (MPGN), eith...

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Main Authors: Edward J. Filippone, Christine Chmielewski, Rakesh Gulati, Eric Newman, John L. Farber
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Case Reports in Transplantation
Online Access:http://dx.doi.org/10.1155/2013/978481
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spelling doaj-8bfa1c6e7661470c9802b085b72fa7bd2020-11-24T22:24:33ZengHindawi LimitedCase Reports in Transplantation2090-69432090-69512013-01-01201310.1155/2013/978481978481De Novo Fibrillary Glomerulonephritis (FGN) in a Renal Transplant with Chronic Hepatitis CEdward J. Filippone0Christine Chmielewski1Rakesh Gulati2Eric Newman3John L. Farber4Department of Medicine, Thomas Jefferson University, 2228 South Broad Street, Philadelphia, PA 19145, USADepartment of Medicine, Thomas Jefferson University, 2228 South Broad Street, Philadelphia, PA 19145, USADepartment of Medicine, Thomas Jefferson University, 2228 South Broad Street, Philadelphia, PA 19145, USADepartment of Medicine, Thomas Jefferson University, 2228 South Broad Street, Philadelphia, PA 19145, USADepartment of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USAChronic hepatitis C viremia (HepC) has been associated with numerous renal manifestations both in native kidneys and in the setting of renal transplantation. Glomerulonephritis (GN) of the renal allograft in the setting of HepC most commonly manifests as type 1 membranoproliferative GN (MPGN), either representing recurrence of the original disease or arising de novo. Other GNs were reported after transplantation in the patient with HepC including membranous nephropathy and thrombotic microangiopathy, as well as an enhanced susceptibility to transplant glomerulopathy. We describe the first case of de novo fibrillary GN in a renal transplant patient with HepC where the primary renal disease was biopsy proven type 1 MPGN. We discuss this relationship in detail.http://dx.doi.org/10.1155/2013/978481
collection DOAJ
language English
format Article
sources DOAJ
author Edward J. Filippone
Christine Chmielewski
Rakesh Gulati
Eric Newman
John L. Farber
spellingShingle Edward J. Filippone
Christine Chmielewski
Rakesh Gulati
Eric Newman
John L. Farber
De Novo Fibrillary Glomerulonephritis (FGN) in a Renal Transplant with Chronic Hepatitis C
Case Reports in Transplantation
author_facet Edward J. Filippone
Christine Chmielewski
Rakesh Gulati
Eric Newman
John L. Farber
author_sort Edward J. Filippone
title De Novo Fibrillary Glomerulonephritis (FGN) in a Renal Transplant with Chronic Hepatitis C
title_short De Novo Fibrillary Glomerulonephritis (FGN) in a Renal Transplant with Chronic Hepatitis C
title_full De Novo Fibrillary Glomerulonephritis (FGN) in a Renal Transplant with Chronic Hepatitis C
title_fullStr De Novo Fibrillary Glomerulonephritis (FGN) in a Renal Transplant with Chronic Hepatitis C
title_full_unstemmed De Novo Fibrillary Glomerulonephritis (FGN) in a Renal Transplant with Chronic Hepatitis C
title_sort de novo fibrillary glomerulonephritis (fgn) in a renal transplant with chronic hepatitis c
publisher Hindawi Limited
series Case Reports in Transplantation
issn 2090-6943
2090-6951
publishDate 2013-01-01
description Chronic hepatitis C viremia (HepC) has been associated with numerous renal manifestations both in native kidneys and in the setting of renal transplantation. Glomerulonephritis (GN) of the renal allograft in the setting of HepC most commonly manifests as type 1 membranoproliferative GN (MPGN), either representing recurrence of the original disease or arising de novo. Other GNs were reported after transplantation in the patient with HepC including membranous nephropathy and thrombotic microangiopathy, as well as an enhanced susceptibility to transplant glomerulopathy. We describe the first case of de novo fibrillary GN in a renal transplant patient with HepC where the primary renal disease was biopsy proven type 1 MPGN. We discuss this relationship in detail.
url http://dx.doi.org/10.1155/2013/978481
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